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Many athletes use anabolic-androgenic steroids (aas) for physical enhancement but the magnitude of these gains and associated adverse effects has not been rigorously quantified. In this study, we used human peripheral blood blood mononuclear cells (PBMCs) to analyze the effects of low doses of a testosterone analog, anabolic-androgenic steroid HMG-CoA reductase inhibiting (Cyp). In comparison to anabolic steroids, Cyp is non-competitive, non-selective with respect to binding HMG-CoA (HMG-CoA) binding. In our experiment, Cyp induced rapid and long-lasting increases across a variety of physiological responses including serum concentrations of growth hormone binding proteins (GHRPs). The induction of Cyp-mediated increases occurred with serum cortisol concentration as measured by the diurnal hormone changes and did not occur with the serum growth hormone binding protein (GHRP) concentration measured by radioimmunoassay. Moreover, the increase was independent of plasma concentrations of a wide range of other hormones. Therefore, the present finding supports the notion of anabolic-androgenic steroids (aas) as an attractive and effective alternative. Similar articles: